Data demonstrated that the median PFS achieved by patients with advanced clear cell RCC who had undergone a prior nephrectomy was 14.8 months – comparing favorably to historical data from trials testing other currently approved multikinase inhibitors in RCC. Hypertension was the most commonly reported treatment-related adverse effect, and was seen in 50 percent of treated patients. Off-target toxicities commonly associated with other targeted therapies, such as mucositis, fatigue and hand-foot syndrome, were low in the tivozanib group notably, which AVEO believes underscores a potential tolerable safety profile and potential for combinability with various other therapeutic agents.What is CFNM? CFNM is often referred to as a kink or a fetish, but a lot of men prefer to think of it as a sex game simply. The truth is that it could be any or all of these things. In its simplest conditions, CFNM means a predicament in which a man is unclothed while in the presence of one or even more females who maintain their clothing on. In some cases, there is no overt erotic conversation. For example, a guy may clean the house in the buff while the clad woman appears on or a nude hubby may browse the paper as he and his bath-robed wife eat breakfast. In other situations, there exists a distinct erotic element involving the guy. For example, the male may masturbate as the woman looks on. Alternatively, the male may be masturbated or fellated by the female . This erotic component may be employed in a ‘surface’ manner or in a role playing manner .