Advancell has three different study centers in Spain. And.. ADMEcell enters into manufacturing and distribution agreement with Advancell ADMEcell, announced that it offers entered into a special contract with Advancell, Barcelona, Spain, to manufacture and distribute the CacoReady Program for the UNITED STATES market. The CacoReady Program is a new, innovative tool made to optimize the right time and costs of evaluating the intestinal absorption of compounds. The kit has been made to provide a Ready-To-Use user-friendly kit and suitable for high-throughput automated procedures. It offers users with the differentiated Caco-2 barrier , plated on 24 – or 96-Transwell plates.However, the neurotropic form of the JC virus regulatory region was detected for the first time in the urine of eight sufferers in whom viruria developed during natalizumab therapy. Thus, JC virus may reactivate and go through neurotropic transformation in the kidneys of natalizumab-treated patients. Our findings claim that monitoring for JC virus in the urine of patients getting natalizumab therapy and in addition, after 18 months, in PBMCs in sufferers with viruria could provide some insight into viral replication. The mechanisms included look like quite particular for JC virus, since we found in our research that BK virus, which also resides in the kidney and shares epitopes with JC virus that are identified by the same people of cytotoxic T cells,26,36 showed no indication of reactivation either in bloodstream or in urine.