A considerable added advantage was found for individuals who had received previous treatment already. In the brand new dossier compiled by the drug producer, the drug was today compared with the appropriate comparator therapy dacarbazine specified by the Federal Joint Committee also for non-pretreated patients. Again, the manufacturer claimed a noticeable gain in survival time and an added benefit thus. This time, IQWiG did not concur with the interpretation: The result was estimated on the basis of an indirect assessment of individual individual data.A possible limitation of this study may be the relatively small sample size, even with the small number however, it yielded an unequivocal result’.
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