$1 Click to read more about the treatment .6 million ecological stoichiometry grant to study how certain nutrients influence the advancement of disease in humans and animals Two University of Kansas and four Arizona State University researchers have obtained an nearly $1.6 million grant from the National Science Foundation to review how certain nutrients have an effect on the advancement of disease in humans and animals. Their research in this specific area will concentrate on a fresh scientific discipline known as ‘ecological stoichiometry.’ It’s an emerging area of analysis that looks, partly, at how nutrients connect to disease.
The drug, MC4R agonist LY2112688, had an elevated affinity for MC4R over MC1R of more than one factor of 30 and over MC3R of more than a factor of 100. Administration of the MC4R agonist to overweight or obese volunteers created the classic symptoms of yawning, stretching, and penile erection connected with activation of central MC4R and a marked short-term increase in blood circulation pressure that was sustained for the 7 days of the drug’s administration. The average increase in systolic and diastolic blood pressure in these research was quantitatively like the difference in blood circulation pressure between MC4R-deficient topics and control subjects. A insufficiency in MC4R appears to be connected with hyperinsulinemia at a rate that is disproportionate to the amount of obesity, and many studies possess implicated hyperinsulinemia as a link between hypertension and obesity.21 Our finding that MC4R deficiency is associated with reduced, rather than increased, blood pressure does not support such a link.