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Although more patients had clinically essential hypotension during medical procedures than afterward, the period of hypotension was considerably longer after individuals left the post-anesthesia treatment unit. For example, in the clonidine group, the median period of clinically essential hypotension during surgery was 15 minutes, whereas on the 1st postoperative day it was 180 minutes. Discussion The POISE-2 trial showed that low-dose clonidine, as compared with placebo, did not decrease the composite outcome of death or non-fatal myocardial infarction in adults undergoing non-cardiac surgery. Moreover, clonidine elevated the risk of essential hypotension clinically, clinically important bradycardia, and nonfatal cardiac arrest.e., clonidine, dexmedetomidine, and mivazerol) included 12 trials involving sufferers who were undergoing noncardiac medical operation; outcomes were reported separately for individuals who were undergoing vascular surgery and the ones who were undergoing non-vascular surgery.