In nearly all cases, individuals' natriuretic peptide levels correlate with their stage of heart failure and can help physicians program treatment, said Mihai Gheorghiade, MD, professor at Northwestern University's Feinberg School of Medicine and lead author of the ASTRONAUT research. It had been surprising to see that our study medication did positively affect sufferers' levels of this peptide, but this positive effect didn’t result in reduced hospitalizations or mortality as we’d have expected. While individuals taking aliskiren in addition to evidence-based heart failure therapy demonstrated improvements in natriuretic peptide levels over time, they also had significantly higher rates of hyperkalemia , worsening renal function and hypotension .If residual leukemic blasts had been seen, a second induction course was given with the same dose and duration of cytarabine plus 45 mg of daunorubicin per square meter for 3 days. After recovery from induction therapy and before assignment to consolidation therapy, complete remission was confirmed by bone marrow aspiration and biopsy. Patients in whom complete remission had not been achieved after a couple of courses of therapy had been withdrawn from the study.