Today follows an effective research collaboration between the companies The license contract announced. Beneath the terms of the new agreement, A.P. Pharma grants Merial a worldwide, exclusive permit to the merchandise for use in treating companion animals . A.P. Pharma will receive an undisclosed upfront payment, development funding and potential future milestones that are in addition to royalties following commercialization. Related StoriesInner ear damage human brain warnings from nerve cellsSpotting the symptoms of advanced prostate cancer tumor: an interview with Brian TomlinsonScripps Florida researchers win $2.P.P.P.P.The collection of vital status up to day 360 was complete for 99.1 percent of the sufferers. Exacerbations There have been 4411 individual episodes of exacerbation among 2691 patients; 44 percent of the individuals with an exacerbation had moderate COPD at the trial onset . The time to the 1st exacerbation was increased by 42 days with tiotropium as compared with salmeterol , corresponding to a 17 percent reduction in risk with tiotropium . Given the truth that significantly less than 50 percent of the patients had an exacerbation , it had been extremely hard to calculate the median time to the first exacerbation; as a result, enough time to the initial exacerbation in the initial quartile of individuals was calculated instead.